Soluble Erythropoietin Receptor Contributes to Erythropoietin Resistance in End-Stage Renal Disease
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Soluble Erythropoietin Receptor Contributes to Erythropoietin Resistance in End-Stage Renal Disease
BACKGROUND Erythropoietin is a growth factor commonly used to manage anemia in patients with chronic kidney disease. A significant clinical challenge is relative resistance to erythropoietin, which leads to use of successively higher erythropoietin doses, failure to achieve target hemoglobin levels, and increased risk of adverse outcomes. Erythropoietin acts through the erythropoietin receptor ...
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1. van Hensbroek MB, Onyiorah E, Jaffar S et al. A trial of artemether or quinine in childrenwith cerebralmalaria.NEngl JMed1996; 335: 69–75 2. Hien TT, Day NPJ, Phu NH et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N Engl J Med 1996; 335: 76–83 3. Karunajeewa HA, Mueller I, Senn M et al. A trial of combination antimalarial therapies in c...
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BACKGROUND It has been reported that a feedback circuit exists between erythropoietin (EPO) concentration and the degree of anemia even in end stage renal disease (ESRD), and growing experience with subcutaneous EPO administration confirms that only slight increases in EPO levels are required to correct renal anemia. Keeping in mind these findings, if a small portion of reserved EPO production ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0009246